Targeting Staphylococcus aureus biofilm-related infections on implanted material with a novel dual-action thermosensitive hydrogel containing vancomycin and a tri-enzymatic cocktail: in vitro and in vivo studies

Targeting Staphylococcus aureus biofilm-related infections on implanted material with a novel dual-action thermosensitive hydrogel containing vancomycin and a tri-enzymatic cocktail: in vitro and in vivo studies

Implant-associated infections remain a critical challenge due to the presence of biofilm-forming bacteria, which enhance tolerance to conventional treatments. This study investigates the efficacy of a tri-enzymatic cocktail (TEC; DNA/RNA endonuclease, endo-14-β-d-glucanase, β-N-acetylhexosaminidase)...

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Bibliographic Details
Main Authors: Randy Buzisa Mbuku, Hervé Poilvache, Loïc Maigret, Rita Vanbever, Françoise Van Bambeke, Olivier Cornu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biofilm
Subjects:
Biofilm
Vancomycin
Enzymatic cocktail
Poloxamer P407 hydrogel
Implant infection
Tissue cage model
Online Access:http://www.sciencedirect.com/science/article/pii/S259020752500036X
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http://www.sciencedirect.com/science/article/pii/S259020752500036X

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