Metabolic reprogramming nanomedicine potentiates colon cancer sonodynamic immunotherapy by inhibiting the CD39/CD73/ADO pathway

Metabolic reprogramming nanomedicine potentiates colon cancer sonodynamic immunotherapy by inhibiting the CD39/CD73/ADO pathway

Sonodynamic therapy (SDT) can potentially induce immunogenic cell death in tumor cells, leading to the release of ATP, and facilitating the initiation of an immune response. Nevertheless, the enzymes CD39 and CD73 can swiftly convert ATP into immunosuppressive adenosine (ADO), resulting in an immuno...

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Bibliographic Details
Main Authors: Yuanyuan Zhang, Weiwei Jin, Zhichao Deng, Bowen Gao, Yuanyuan Zhu, Junlong Fu, Chenxi Xu, Wenlong Wang, Ting Bai, Lianying Jiao, Hao Wu, Mingxin Zhang, Mingzhen Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Sonodynamic therapy
Immunotherapy
Ag2S quantum dots
POM1
Colon cancer
CD39/CD73/ADO pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352500214X
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