RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells

RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells

RNF213 encodes a unique protein with AAA+ ATPase and E3 ubiquitin ligase activities that are critical for its diverse roles, which range from involvement in human vasculopathies, such as Moyamoya disease, to ubiquitination of viral and bacterial pathogens. Nevertheless, its primary functions in huma...

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Bibliographic Details
Main Authors: Jungmi Choi, Ryoichi Inoue, Yuki Masuo, Yukiko Shimizu, Kazuhiro Sonomura, Minsoo Kim, Hatasu Kobayashi, Kouji H. Harada, Yohei Mineharu, Akio Koizumi, Tohru Tezuka, Shohab Youssefian
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
RNF213
moyamoya disease
MMD
caveolin-1
Cav-1
Online Access:https://www.mdpi.com/2073-4409/14/11/775
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