Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

Abstract Immune dysregulation-induced inflammation serves as a driving force in the progression of metabolic dysfunction-associated steatohepatitis (MASH), while the underlying cellular and molecular mechanisms remain largely uncharted. A Western diet (WD) is employed to construct mouse models of me...

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Main Authors: Yuxiang Song, Na Li, Shang Jiang, Kexin Wang, Guoyue Lv, Zhongqi Fan, Xiliang Du, Wenwen Gao, Lin Lei, Zhe Wang, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57574-3
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https://doi.org/10.1038/s41467-025-57574-3

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