DIRAS1 Drives Oxaliplatin Resistance in Colorectal Cancer via PHB1-Mediated Mitochondrial Homeostasis

DIRAS1 Drives Oxaliplatin Resistance in Colorectal Cancer via PHB1-Mediated Mitochondrial Homeostasis

Background: Colorectal cancer (CRC) is a prevalent global malignancy with particularly challenging treatment outcomes in advanced stages. Oxaliplatin (OXA) is a frontline chemotherapeutic agent for CRC. However, 15% to 50% of stage III patients experience recurrence due to drug resistance. Elucidati...

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Main Authors: Min Long, Qian Ouyang, Jingyi Wen, Xuan Zeng, Zihui Xu, Shangwei Zhong, Changhao Huang, Jun-Li Luo
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
colorectal cancer
oxaliplatin resistance
DIRAS1
PHB1
mitochondrial function
targeted therapy
Online Access:https://www.mdpi.com/2079-7737/14/7/819
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