Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA

Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA

Abstract Background The evolution of SARS-CoV-2, particularly through new variants, presents significant global health challenges due to their potential for immune evasion and reduced vaccine effectiveness. This study aims to investigate the impact of mutations in the Spike protein of Omicron EG.5 a...

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Bibliographic Details
Main Authors: Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky, Wei-Chiao Chang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Biomedical Science
Subjects:
SARS-CoV-2
Omicron variant
Spike protein
T-CoV
HLA
Online Access:https://doi.org/10.1186/s12929-025-01139-5
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https://doi.org/10.1186/s12929-025-01139-5

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