Implant-Derived <i>S. aureus</i> Isolates Drive Strain-Specific Invasion Dynamics and Bioenergetic Alterations in Osteoblasts

Implant-Derived <i>S. aureus</i> Isolates Drive Strain-Specific Invasion Dynamics and Bioenergetic Alterations in Osteoblasts

<b>Background:</b> Implants are integral to modern orthopedic surgery. The outcomes are good, but infections remain a serious issue. <i>Staphylococcus aureus</i> (<i>S. aureus</i>), along with <i>Staphylococcus epidermidis</i>, are predominant pathogen...

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Main Authors: Lei Song, Lea-Sophie Schwinn, Juliane Barthel, Vanessa Ketter, Philipp Lechler, Uwe Linne, Ardawan J. Rastan, Sebastian Vogt, Steffen Ruchholtz, Jürgen R. J. Paletta, Madeline Günther
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antibiotics
Subjects:
implant infections
<i>S. aureus</i>
clinical isolates
SaOS2 and MG63 osteoblasts
adhesion-, invasion- and survival assay
mitochondrial respiration
Online Access:https://www.mdpi.com/2079-6382/14/2/119
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