Validation of an LC-MS/MS method for urinary homovanillic and vanillylmandelic ACIDS and application to the diagnosis of neuroblastoma

Validation of an LC-MS/MS method for urinary homovanillic and vanillylmandelic ACIDS and application to the diagnosis of neuroblastoma

Background: Urinary catecholamine metabolites are well-established biomarkers for neuroblastoma (NB). Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are the most frequently measured metabolites within SIOPEN – Catecholamine Working Group laboratories. Here, we evaluated the performance of a...

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Main Authors: Lucilla Rossi, Yvette A.H. Matser, Sebastiano Barco, Alessia Cafaro, Federica Pigliasco, Margherita Biondi, Fabrizio Mancin, Maria van der Ham, Monique G.M. de Sain-van der Velden, Shifra Ash, Maja Beck Popovic, André B.P. van Kuilenburg, Massimo Conte, Alberto Garaventa, Godelieve A.M. Tytgat, Giuliana Cangemi
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Subjects:
Neuroblastoma
Urinary catecholamine
Liquid Chromatography-tandem Mass Spectrometry
Pediatrics
Inter-laboratory harmonization
Homovanillic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X25000148
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