Adaptations of lipid metabolism in low-grade clear cell renal cell carcinoma are linked to cholesteryl ester accumulation

Adaptations of lipid metabolism in low-grade clear cell renal cell carcinoma are linked to cholesteryl ester accumulation

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by the accumulation of high quantities of lipids in cytoplasmic lipid droplets. Owing to the tissue heterogeneity of ccRCC, adjacent biopsies from a tumor can diverge substantially in molecular characteristics. To elucidate metabolic...

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Bibliographic Details
Main Authors: Olatz Fresnedo, Jose Antonio Lopez-Gomez, Carlos Ceniceros, Gorka Larrinaga, Alberto Saiz, Lorena Mosteiro, Hiart Navarro-Imaz, Yuri Rueda
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
AADAC
ccRCC
Cholesteryl ester accumulation
Kidney
Lipidomics
Lysosomal acid lipase
Online Access:https://doi.org/10.1038/s41598-025-09664-x
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https://doi.org/10.1038/s41598-025-09664-x

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