HLA-B*58:01 genotyping prevalence and the association with allopurinol-induced severe cutaneous adverse reactions: a living systematic review and meta-analysis

HLA-B*58:01 genotyping prevalence and the association with allopurinol-induced severe cutaneous adverse reactions: a living systematic review and meta-analysis

Abstract Evidence on the prevalence of HLA-B*58:01 genotyping and its association with allopurinol-induced severe cutaneous adverse reactions (SCARs) is lacking, especially in low-resource settings. We addressed these gaps by conducting comprehensive and race/ethnic origin-specific evaluations. We c...

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Bibliographic Details
Main Authors: Hong Tham Pham, Manh Hung Tran, Thuy-Van Mai Hoang, Ai-Hoc Nguyen, Minh-Hoang Tran
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
HLA-B*58:01
Allopurinol
Drug hypersensitivity
Severe cutaneous adverse reaction
Online Access:https://doi.org/10.1038/s41598-025-16062-w
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https://doi.org/10.1038/s41598-025-16062-w

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