Fc-Elabela mitigates heart failure without liver and renal toxicity in mice

Fc-Elabela mitigates heart failure without liver and renal toxicity in mice

AimsElabela (ELA) is a ligand of the APJ receptor and exhibits anti-heart failure activities. However, the short half-life of the ELA limits its clinical applications. Our previous study recombined the short peptide ELA-21 and the Fc fragment of human IgG into a long-acting Fc-ELA-21 fusion protein...

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Bibliographic Details
Main Authors: Huifen Zhou, Da-Wei Gong, Ling Chen, Hui Chen, Quan Wang, Mustajab Ullah, Saleem Ahmad, Ishtiaq Jeelani, Qingbin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Elabela
Fc fusion protein
heart failure
vascular endothelial growth factor receptor
myocardial infarction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555728/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555728/full

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