ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

Abstract Lactate derived from aerobic glycolysis is crucial for DNA damage repair and chemoresistance. Nevertheless, it is frequently noted that cancer cells depend on glutaminolysis to replenish essential metabolites. Whether and how glutaminolysis might enhance lactate production and facilitate DN...

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Bibliographic Details
Main Authors: Cuimiao Zheng, Hao Tan, Gang Niu, Xi Huang, Jingyi Lu, Siqi Chen, Haoyuan Li, Jiayu Zhu, Zhou Zhou, Manman Xu, Chaoyun Pan, Junxiu Liu, Jie Li
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
ME2
acetylation
lactylation
platinum resistance
Online Access:https://doi.org/10.1002/advs.202416467
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https://doi.org/10.1002/advs.202416467

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