Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum

Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum

Abstract Despite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules. This article describes the development and...

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Bibliographic Details
Main Authors: Khalisa Amir Hamzah, Leisa-Maree Toms, Nathaniel Kucharski, Julia Orr, Peter Hobson, David S. Nichols, Luke J. Ney
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Neurosteroids
Allopregnanolone
Testosterone
Liquid chromatography tandem mass spectrometry
Age and sex effects
Online Access:https://doi.org/10.1038/s41598-024-78807-3
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https://doi.org/10.1038/s41598-024-78807-3

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