Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grad...

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Main Authors: Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Cancer Communications
Subjects:
effector regulatory T cells
high‐grade serous ovarian cancer
Jagged2
programmed cell death 1
Tumor‐associated neutrophils
Online Access:https://doi.org/10.1002/cac2.70021
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https://doi.org/10.1002/cac2.70021

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