Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation

Over the past 25 years, nuclear envelope (NE) perturbations have been reported in various experimental models with mutations in the LMNA gene. Although the hypothesis that NE perturbations from LMNA mutations are a fundamental feature of striated muscle damage has garnered wide acceptance, the molec...

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Bibliographic Details
Main Author: Jason C. Choi
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Nucleus
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19491034.2024.2449500
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