Pixel super-resolved virtual staining of label-free tissue using diffusion models

Abstract Virtual staining of tissue offers a powerful tool for transforming label-free microscopy images of unstained tissue into equivalents of histochemically stained samples. This study presents a diffusion model-based pixel super-resolution virtual staining approach utilizing a Brownian bridge p...

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Bibliographic Details
Main Authors: Yijie Zhang, Luzhe Huang, Nir Pillar, Yuzhu Li, Hanlong Chen, Aydogan Ozcan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60387-z
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