The development and validation of a microneutralization assay for the detection and quantification of anti-yellow fever virus antibodies in human serum

The development and validation of a microneutralization assay for the detection and quantification of anti-yellow fever virus antibodies in human serum

ABSTRACT The plaque reduction neutralization test (PRNT) has been used widely for the detection and quantitation of yellow fever (YF) virus-neutralizing antibodies in human serum; however, it is labor-intensive and challenging to adapt to high-throughput clinical testing needed for vaccine licensure...

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Main Authors: Katherine Fries, Ping Luo, Rebekah Baldwin, Raechel Goldberg, Ivan Ordonez, Lingyi Zheng, James Huleatt, Louis Devlin
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:Microbiology Spectrum
Subjects:
assay development
assay validation
microneutralization assay
neutralizing antibodies
orthoflavivirus
yellow fever virus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03348-24
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https://journals.asm.org/doi/10.1128/spectrum.03348-24

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