Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies.

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies.

Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1-29) was synthesized, and evaluated for in vitro thym...

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Bibliographic Details
Main Authors: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Rizwana Malik, Khalid Mohammed Khan, M Iqbal Choudhary, Atta-Ur Rahman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0227549/1/pone.0227549.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T071503Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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