A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

Gut microbial metabolism of dietary flavonoids leads to a diverse array of bioactive products that are closely associated with human health. Combining enzyme promiscuity prediction, metabolomics, and in vitro model systems, we identified a chalcone-synthase-like bacterial polyketide synthase that ca...

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Bibliographic Details
Main Authors: Ebru Ece Gülşan, Farrhin Nowshad, Meredith Davis Leigh, Jimmy Walter Crott, Hyejin Park, Greg Martin, Stephen Safe, Robert S. Chapkin, Arul Jayaraman, Kyongbum Lee
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Metabolites
Subjects:
flavonoids
naringenin
ring cleavage
gut microbiome
aryl hydrocarbon receptor
Online Access:https://www.mdpi.com/2218-1989/15/3/146
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