Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need to develop novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to conventional antimicrobial therapies. Antimicrobial peptides have b...

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Main Authors: Ka Kiu Lee, Urszula Łapińska, Giulia Tolle, Maureen Micaletto, Bing Zhang, Wanida Phetsang, Anthony D Verderosa, Brandon M Invergo, Joseph Westley, Attila Bebes, Raif Yuecel, Paul A O'Neill, Audrey Farbos, Aaron R Jeffries, Stineke van Houte, Pierluigi Caboni, Mark AT Blaskovich, Benjamin E Housden, Krasimira Tsaneva-Atanasova, Stefano Pagliara
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
antibiotics
antimicrobial resistance
membrane transport
heterogeneity
efflux pumps
microfluidics
Online Access:https://elifesciences.org/articles/99752
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https://elifesciences.org/articles/99752

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