Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes

IntroductionThe regulation of immune responses to promote tolerance to the fetus is critical for successful pregnancy. An understudied aspect of this process is the initiation of regulation pre-conception via exposure to semen. Our study aimed to understand how semen impacts recipient dendritic cell...

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Main Authors: Shahrokh Paktinat, Michael G. Gravett, Cara Tobey, Anna Kirby, Whitney Horner, Rebecca Shaffer, Michael Fialkow, Nam Phuong Nguyen, Germán G. Gornalusse, Maryam Kalatehjari, Sean M. Hughes, Florian Hladik, Lucia Vojtech
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
pregnancy
semen
tolerance
extracellular vesicle
dendritic cells
regulatory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564002/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564002/full

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