Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection

Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection

Abstract Background Schistosomiasis, a parasitic disease affecting more than 240 million people worldwide, is characterized by chronic inflammation and tissue fibrosis primarily induced by parasite egg deposition. Bromodomain-containing protein 4 (BRD4), an epigenetic and transcriptional regulator,...

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Bibliographic Details
Main Authors: Ming Yuan, Mingrou Wu, Yunyi Hu, Siyu Zhao, Jehangir Khan, Zhanhong Yuan, Yun Huang, Tianqiong He, Zhijun Zhou, Jia Shen, Zhongdao Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
BRD4
Schistosomiasis
Immune response
Proinflammation
Online Access:https://doi.org/10.1186/s13071-025-06821-z
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https://doi.org/10.1186/s13071-025-06821-z

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