166Dy/166Ho-labeled porous hydroxyapatite microparticles for treatment of inflammatory joint diseases – Exploring the advantages of in vivo generator

166Dy/166Ho-labeled porous hydroxyapatite microparticles for treatment of inflammatory joint diseases – Exploring the advantages of in vivo generator

Abstract Holmium-166 [T½ = 26.8 h, Eβ − (max) = 1.74 MeV (48.7%) and 1.85 MeV (50.0%); Eγ = 80.6 keV (10.6%)] is one of the most promising radionuclides in radiation synovectomy (RSV) for the treatment of inflammatory joint diseases, especially of large joints. However, short half-life of 166Ho is a...

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Bibliographic Details
Main Authors: Sourav Patra, Khajan Singh, Avik Chakraborty, Shahiralam Khan Mohammed, Sutapa Rakshit, Rubel Chakravarty, Sudipta Chakraborty
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Radiation synovectomy
166Dy/166Ho equilibrium mixture
In vivo generator
Porous hydroxyapatite
Sorption capacity
Online Access:https://doi.org/10.1038/s41598-025-02373-5
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https://doi.org/10.1038/s41598-025-02373-5

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