Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling

Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling

Background: The therapeutic utility of the effective chemotherapeutic agent cisplatin is hampered by its nephrotoxic effect. We aimed from the current study to examine the possible protective effects of amlodipine through gamma-glutamyl transpeptidase (GGT) enzyme inhibition against cisplatin nephro...

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Bibliographic Details
Main Authors: Amany A. Azouz, Esraa Abdel-Nassir Abdel-Razek, Amira M. Abo-Youssef
Format: Article
Language:English
Published: Springer 2020-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
Cisplatin nephrotoxicity
Amlodipine
GGT inhibition
Anti-oxidant defense
Anti-inflammatory response
Renal cell survival
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016420302024
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