Multicentre double-blind randomised placebo-controlled four-arm trial to assess the effect of oral sodium bicarbonate and intravenous hyoscine butylbromide on spontaneous delivery after induction of labour in nulliparous women: protocol for the Safe Induction of Labour Trial (SAINT)

Multicentre double-blind randomised placebo-controlled four-arm trial to assess the effect of oral sodium bicarbonate and intravenous hyoscine butylbromide on spontaneous delivery after induction of labour in nulliparous women: protocol for the Safe Induction of Labour Trial (SAINT)

Introduction Presently, more than one in four births in high-income countries undergo labour induction. Induction of labour is an independent risk factor for adverse obstetric outcomes, including high rates of operative delivery. Two drugs, hyoscine butylbromide and sodium bicarbonate, have been use...

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Main Authors: Anne Flem Jacobsen, Trond Melbye Michelsen, Elisabeth Balstad Magnussen, Nina Gunnes, Ragnar Kvie Sande, Camilla Haavaldsen, Ingvil Krarup Sørbye, Aslak Vimme Solhoff, Jørg Kessler, Anne Molne Kjøllesdal, Åse Torunn Revholdt Pettersen, Katrine Dønvold Sjøborg, Marte Eline Ween-Velken, Lisa Tangnes Leeves, Tonje Lippert, Elisabeth Magnussen, ÅseTorunn Revholt Pettersen, Marte Ween-Velken
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/3/e093992.full
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https://bmjopen.bmj.com/content/15/3/e093992.full

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