Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system

Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system

Osteoarthritis (OA) remains a challenging degenerative joint disease, largely associated with chondrocyte apoptosis during its development. Preserving chondrocytes stands as a promising strategy for OA treatment. Rapamycin (RP) exhibits chondrocyte protection by fostering autophagy. Nevertheless, th...

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Bibliographic Details
Main Authors: Guangyong Lin, Huirong Huang, Meng Sun, Zhinan He, Shengjie Li, Xindan Liang, Yuqi Yan, Chenyu Qiu, Shize Li, Xinyu Zhao, Wanling Zhu, Longfa Kou, Ruijie Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
Two-stage nanoparticle
Osteoarthritis
Rapamycin
Autophagy
Chondrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003405
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