Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Abstract Stress granules (SGs) fulfill a pivotal role in host defense mechanisms, by sequestering both mRNA and protein via the process of liquid–liquid phase separation (LLPS). In this study, we showed that perillaldehyde (PAE), a natural occurring compound, bound directly to the core protein of SG...

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Main Authors: Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
α‐synuclein
G3BP
histone deacetylase 6
liquid–liquid phase separation
Parkinson's disease
perillaldehyde
Online Access:https://doi.org/10.1002/advs.202412152
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https://doi.org/10.1002/advs.202412152

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