Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.

Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.

<h4>Background</h4>Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis. As vascular calcification is cons...

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Main Authors: Leon J Schurgers, Ivo A Joosen, Eduard M Laufer, Martijn L L Chatrou, Marjolein Herfs, Mark H M Winkens, Ralf Westenfeld, Verena Veulemans, Thilo Krueger, Catherine M Shanahan, Willi Jahnen-Dechent, Erik Biessen, Jagat Narula, Cees Vermeer, Leonard Hofstra, Chris P Reutelingsperger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043229&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043229&type=printable

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