Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

BackgroundValeriana jatamansi Jones, a globally utilized medicinal plant, exhibits favorable pharmacological effects against depression and tumors. Iridoids derived from V. jatamansi (IRFV) promote recovery following spinal cord injury (SCI). Inflammation and disruption of the blood-spinal cord barr...

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Bibliographic Details
Main Authors: Yongzhi He, Jiachun Lu, Rizhao Pang, Lijuan Ding, Yunyun Wang, Hua Xiao, Chao Cheng, Yushan Luo, Xiaoming Hu, Wenchun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
spinal cord injury
neuroinflammation
Nrf2/HO-1 signaling pathway
blood-spinal cord barrier
Valeriana jatamansi Jones
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1597719/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1597719/full

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