Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer

Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer

Prostate cancer (PCa) is not only one of the most diagnosed malignancies in men but also a leading cause of cancer-related mortality globally. PCa exhibits unique metabolic dependencies, particularly on lipids and glutamine, unlike many solid tumors, rather than glycolysis. Methionine metabolism pla...

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Bibliographic Details
Main Authors: Serdar Arisan, Ayyuce Sever, Pinar Obakan-Yerlikaya, Elif Damla Arisan, Pinar Uysal-Onganer
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biology
Subjects:
mTOR
SAMTOR
methionine
prostate cancer
autophagy
Online Access:https://www.mdpi.com/2079-7737/14/5/507
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