Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy

Abstract Background Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches. Methods We constructed a single-cell trans...

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Bibliographic Details
Main Authors: Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Dilated cardiomyopathy (DCM)
Single-cell RNA sequencing (scRNA-seq)
Bulk RNA sequencing (Bulk RNA-seq)
Non-cardiomyocytes
Heterogeneity
Online Access:https://doi.org/10.1186/s12967-024-05983-1
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