The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis

The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis

Aims: This study investigates how plasma exosomal miRNAs regulate core fucosylation (CF)-modified targets to influence autophagy and fibrosis in idiopathic pulmonary fibrosis (IPF), aiming to identify novel therapeutic strategies targeting dysregulated alveolar epithelial cell (AEC) autophagy. Mater...

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Bibliographic Details
Main Authors: Yina Li, Nan Wang, Jinying Hu, Minlan Luo, Na Zhang, Lili Gao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Non-coding RNA Research
Subjects:
Pulmonary interstitial fibrosis
Exosomes
Autophagy
miRNA
Core fucosylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054025000769
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http://www.sciencedirect.com/science/article/pii/S2468054025000769

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