Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats

Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats

Objective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions. However, the role of HDAC3 in early surgical brain injury (SBI) remains elus...

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Bibliographic Details
Main Authors: Haiping Gu, Yating Gong, Muyao Wu, Mengying Shi, Jiejie Yu, Hongfei Zhu, Ya-ming Sun, Baoqi Dang
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
autophagy
brain injury
hdac3
inflammation
npas4
Online Access:https://ijbms.mums.ac.ir/article_25891_d900d626d5932b4a94f7db288fbff10d.pdf
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https://ijbms.mums.ac.ir/article_25891_d900d626d5932b4a94f7db288fbff10d.pdf

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