Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-δ

Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-δ

Heart failure with preserved ejection fraction (HFpEF) presents a significant challenge to global healthcare systems due to its complex presentation. HFpEF presents with a normal or near-normal left ventricular ejection fraction, cardiac diastolic dysfunction, and a metabolic profile characterized b...

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Bibliographic Details
Main Authors: Haiying Zhang, Yanan Gao, Min Zhang, Zhexin Yuan, Yu Chen, Aiping Wang, Xinxing Liu, Shunchang Ji, Jianfeng Jin, Jingwei Liang, Yan Liu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Redox Biology
Subjects:
HFpEF
Schaftoside
Autophagy
CaMKII-δ
Allosteric inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004026
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