Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

New <b>EA</b>-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{<sup>1</sup>H and <sup>13</sup>C...

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Bibliographic Details
Main Authors: Nassima Saghdani, Nabil El Brahmi, Abdelmoula El Abbouchi, Rachid Haloui, Souad Elkhattabi, Gérald Guillaumet, Saïd El Kazzouli
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Chemistry
Subjects:
cancer
ethacrynic acid
indazole
sulfonamide
docking study
molecular dynamics simulation
Online Access:https://www.mdpi.com/2624-8549/6/6/83
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