Ginsenoside Rb1 alleviates renal tubular epithelial cell injury in diabetic kidney disease by inhibiting the aldose reductase activity

Ginsenoside Rb1 alleviates renal tubular epithelial cell injury in diabetic kidney disease by inhibiting the aldose reductase activity

ObjectiveTo investigate the protective effect of ginsenoside Rb1 on renal tubular epithelial cell injury in diabetic kidney disease and its mechanism.MethodsPrimary human renal cortical proximal tubular epithelial cells （HK-2） were cultured in vitro. HK-2 cells were divided into the control group， c...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wang Meng-jing, Luo Yi, Liu Shu-fen, Yuan Shuang, Huang Hao
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Nephrology 2025-07-01
Series:	Linchuang shenzangbing zazhi
Subjects:	Ginsenoside Rb1 Diabetic kidney disease Aldose reductase Renal tubular epithelial cell
Online Access:	http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.07.009
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence
by: Gautham Yepuri, et al.
Published: (2024-12-01)

Determinatin of Aldose Reductase (AR) activity in Diabetic Patients
by: Ferah Ghali Al-Salihi, et al.
Published: (2023-02-01)

Repositioning of rhodanine-thiazole hybrids as aldose reductase inhibitors
by: Shankar Gharge, et al.
Published: (2025-09-01)

Computational screening identifies selective aldose reductase inhibitors with strong efficacy and limited off target interactions
by: Jicli Jose Rojas, et al.
Published: (2025-08-01)

Ameliorating effect of the aldose reductase inhibitor 1-Acetyl-5-phenyl-1 H-pyrrol-3-ylacetate on galactose-induced cataract
by: Xi Wang, et al.
Published: (2025-04-01)

Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway
by: Xiaoyan Bi, et al.
Published: (2025-08-01)

Spectrophotometric Determination of para aminosalicylic acid in Serum Blood and Urin By Oxidative Coupling With 4-Amino Antipyrine and Study The Inhibition of Aldose Reductase Enzyme
by: Asma'a H. Shakir
Published: (2023-02-01)

Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase
by: Francesco Balestri, et al.
Published: (2022-12-01)

Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells
by: Jianqiang Zhang, et al.
Published: (2019-12-01)

Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant
by: Shuhui Zhuang, et al.
Published: (2025-02-01)

1H NMR metabonomic analysis of serum and flap tissue on the effect of ginsenoside Rb1 on survival of random pattern skin flaps in rats
by: Yeqian Huang, et al.
Published: (2025-03-01)

Targeted metabolomics reveals the role of ginsenoside Rb1 in modulating inflammation and cellular senescence in sepsis-induced acute lung injury
by: Fushuang Zheng, et al.
Published: (2025-06-01)

Coordinated gene expression and hormonal fluxes dictating ginsenoside Rb3 biosynthesis in floral development of Panax notoginseng
by: Can Wang, et al.
Published: (2025-02-01)

Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury
by: Ruo-jing Liu, et al.
Published: (2025-08-01)

Ginsenoside Rb1 ameliorates post-doxorubicin treatment myocardial hypertrophy via CaN/NFATc4/GATA4
by: Jin-Jin Chang, et al.
Published: (2025-09-01)

Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics analysis
by: Rongfang Guo, et al.
Published: (2025-05-01)

Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation
by: Zhenni Yang, et al.
Published: (2025-07-01)

Effect of calcitriol on up-regulated expression of renin in renal tubular epithelial cells induced by high glucose
by: HAO Tian-ya, et al.
Published: (2016-01-01)

Oxoglutarate dehydrogenase-L regulates mitochondrial metabolism reprogramming of renal tubular epithelial cells to alleviate renal fibrosis
by: YANG Yingxian, et al.
Published: (2025-06-01)

ARA290 inhibits apoptosis of renal tubular epithelial cells in diabetic rats
by: DANG Jian-zhong, et al.
Published: (2019-01-01)

Role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage
by: WANG Rui, et al.
Published: (2016-01-01)

Ginsenoside Rb<sub>1</sub> Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
by: Ziwei Zhou, et al.
Published: (2025-03-01)

DNA-PKcs participates in the repair of renal tubular epithelial cell injury
by: Dan Feng, et al.
Published: (2025-12-01)

Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems
by: Xiangyuan Jin, et al.
Published: (2025-06-01)

Renal tubular epithelial cell related partial epithelial-mesenchymal transition in AAⅠ induced renal fibrosis via Wnt7b/β-catenin signaling
by: Yi-Fan Wang, et al.
Published: (2025-05-01)

The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells
by: Xiao-Cui Jiao, et al.
Published: (2025-08-01)

Effects of chikusetsu saponin Ⅳa on high glucose-induced human renal tubular epithelial cell injury through regulating circEIF4G2/miR-379-5p
by: Qin Li, et al.
Published: (2022-06-01)

Homocysteine induces ferroptosis in renal tubular epithelial cells via β-catenin/GPX4 signaling pathway
by: Yanping Lei, et al.
Published: (2025-07-01)

Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis
by: Lingzhi Huang, et al.
Published: (2025-06-01)

Single-Cell Profiling of Tubular Epithelial Cells in Adaptive State in the Urine Sediment of Patients With Early and Advanced Diabetic Kidney Disease
by: Dongzhao Ma, et al.
Published: (2025-03-01)

Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells
by: Xin Kang, et al.
Published: (2025-07-01)

Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism
by: Jiang H, et al.
Published: (2025-06-01)

Effect of apigenin regulating lncRNA MEG8 on high glucose-induced injury of human renal tubular epithelial cells
by: Lu Di, et al.
Published: (2022-01-01)

Effects and mechanisms of telmisartan on adiponectin receptors in rat renal proximal tubular epithelial cells induced by high glucose
by: BU Xi, et al.
Published: (2019-01-01)

DPP8 and DPP9 promote tubular epithelial cell ferroptosis in acute kidney injury
by: Kexin Guan, et al.
Published: (2025-07-01)

Profiling the Differential Distribution of Ginsenosides Across Ginseng Tissues Using High-Resolution Mass Spectrometry
by: Hang Xu, et al.
Published: (2025-06-01)

A Novel Ginsenoside-Transforming α-L-Rhamnosidase from <i>Bifidobacterium</i>: Screening, Characterization and Application
by: Chang-Hao Cui, et al.
Published: (2024-12-01)

ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling
by: Xinran Liu, et al.
Published: (2025-12-01)

Effects of miR-4429/NQO1 on high glucose-induced renal tubular epithelial injury and inflammatory factor secretion
by: ZHOU Yan, et al.
Published: (2020-01-01)

Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy
by: Ying Lu, et al.
Published: (2025-07-01)