Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones

Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones

Abstract Purpose Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(−), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM cells in each ULM subtype. Methods ULM...

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Bibliographic Details
Main Authors: Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Reproductive Medicine and Biology
Subjects:
female hormones
mediator complex subunit 12 (MED12) mutation
selective progesterone receptor modulator
spheroid
uterine leiomyomas
Online Access:https://doi.org/10.1002/rmb2.12627
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https://doi.org/10.1002/rmb2.12627

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