A Refined Model of the CFTR Membrane Transporter as a Tool to Revert Misbehavior

A Refined Model of the CFTR Membrane Transporter as a Tool to Revert Misbehavior

ABC proteins are large transmembrane efflux pumps that export substrates against the concentration gradient through ATP hydrolysis. Due to their efflux capabilities, they are crucial in drug metabolism. Point mutations in ABC proteins can lead to many forms of illness by causing protein misfolding a...

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Bibliographic Details
Main Authors: Pedro M. S. Suzano, Michael González-Durruthy, Ricardo J. Ferreira, Cátia A. Bonito, Margarida D. Amaral, Daniel J. V. A. dos Santos
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Chemistry Proceedings
Subjects:
cystic fibrosis
molecular modeling
ABC efflux transporters
molecular dynamics
Online Access:https://www.mdpi.com/2673-4583/16/1/109
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