A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing

A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing

Abstract Herpes simplex virus (HSV) causes significant health burden worldwide. Currently used antiviral drugs are effective but resistance can occur. Here, we report two high-affinity neutralizing nanobodies, namely Nb14 and Nb32, that target non-overlapping epitopes in HSV gD. Nb14 binds a neutral...

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Main Authors: Jing Hu, Haoyuan Tan, Meihua Wang, Shasha Deng, Mengyao Liu, Peiyi Zheng, Anmin Wang, Meng Guo, Jin Wang, Jiayin Li, Huanwen Qiu, Chengbing Yao, Zhongliang Zhu, Chaolu Hasi, Dongli Pan, Hongliang He, Chenghao Huang, Yuhua Shang, Shu Zhu, Tengchuan Jin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58669-7
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https://doi.org/10.1038/s41467-025-58669-7

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