Enhancing the potency of 5T4 mRNA vaccine by CD70 mRNA-LNPs through ADCC and T cell boosting in prostate cancer therapy

Abstract Background Prostate cancer remains a significant health challenge, as conventional treatments often fail to provide long-term benefits in the advanced stages. This study explored the potential of mRNA vaccines as novel therapeutic strategies, specifically focusing on the combination of 5T4...

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Bibliographic Details
Main Authors: Fei Cao, Yuandong Xu, Yupeng Guan, Kexin Zhang, Haowei Qiu, Zhen Xu, Yunru He, Ze Xiu Xiao, Gao-feng Zha, Jun Pang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03607-4
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