Stability and functional consequences of disulfide bond engineering in Aspergillus flavus uricase

Stability and functional consequences of disulfide bond engineering in Aspergillus flavus uricase

Abstract Disulfide bond engineering is a promising strategy for enhancing the stability and functional lifespan of enzymes in therapeutic and industrial applications. In this study, we applied computational modeling to introduce interchain disulfide bonds in Aspergillus flavus uricase to increase it...

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Bibliographic Details
Main Authors: Mohammad Reza Rahbar, Navid Nezafat, Mohammad Hossein Morowvat, Amir Savardashtaki, Mohammad Bagher Ghoshoon, Mohammad Soroosh Hajizade, Younes Ghasemi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Disulfide Bond Engineering
Uricase Stability
Energetic Frustration
Protein Folding Dynamics
Enzyme Tunnel Profiling
In Silico Protein Design
Online Access:https://doi.org/10.1038/s41598-025-01683-y
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https://doi.org/10.1038/s41598-025-01683-y

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