Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway

Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway

The mechanisms underlying environmental endocrine disruptors (EEDs)-induced cardiovascular diseases (CVDs) are not well understood. Specifically, it is unclear whether nonylphenol (NP) exposure regulates myocardial fibrosis (MF) by activating myosin light chain (MLC) through the Ras homolog gene fam...

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Bibliographic Details
Main Authors: Mucong Zheng, Shixu Li, Jie Xu, Ya Luo, Jie He, Chengxing Wang, Yuzhu Xu, Yingxi Zeng, Jie Yu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Nonylphenol
Cardiac fibroblasts
RhoA/ROCK1/MLC pathway
Myocardial fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325007596
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