Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia–reperfusion by regulating the SIRT1/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle

Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia–reperfusion by regulating the SIRT1/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle

Abstract Background Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine formula for cerebral infarction, exerts neuroprotective effects by enhancing cerebral energy metabolism, yet its precise mechanisms remain elusive. Objective To explore the effects of BYHWD on improving cerebral isch...

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Bibliographic Details
Main Authors: Zhongji Hu, Nujiao Deng, Yanling Li, Yang Bai, Xiao Lan, Tingting Xiong, Huang Ding, Xiaodan Liu, Changqing Deng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Chinese Medicine
Subjects:
Qi deficiency and blood stasis syndrome
Cerebral ischemia reperfusion injury
Buyang Huanwu Decoction
Energy metabolism
Metabolomics
Glycolysis
Online Access:https://doi.org/10.1186/s13020-025-01163-5
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https://doi.org/10.1186/s13020-025-01163-5

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