Morin combined with meropenem is a potent inhibitor of NDM-1 against NDM-1-producing E. coli

Morin combined with meropenem is a potent inhibitor of NDM-1 against NDM-1-producing E. coli

Abstract Some β-lactam antibiotics are hydrolyzed by the enzyme New Delhi metallo-β-lactamase 1 (NDM-1), increasing antibiotic resistance and posing a significant threat to public health. Thus, there is an urgent need to develop and use potent inhibitors of NDM-1 and other β-lactamases. This study e...

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Bibliographic Details
Main Authors: Qinghai Ren, Boyang Zhang, Minge Wang, Tongtong Wang, Wei Zhang, Li Du, Meng Yu, Yubao Li, Xiaoting Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
NDM-1 inhibitors
Morin
MEM
Resistance to β-lactams
Combination antibiotic therapies
Online Access:https://doi.org/10.1038/s41598-025-08532-y
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https://doi.org/10.1038/s41598-025-08532-y

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