Exploration of the antitumor effect and mechanism of gambogic acid on osteosarcoma through network pharmacology and experimental pharmacology study

Abstract Osteosarcoma (OS) is a highly aggressive bone cancer in children and adolescents with extremely poor prognosis. Gambogic acid (GA) is a natural compound derived from the resin of Garcinia hanburyi trees and has been reported to possess multiple antitumor effects. However, the comprehensive...

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Bibliographic Details
Main Authors: Mei Hu, Zhe Zhang, Cui Yan, Ximin Wang, Jun Tong, Guangru Li, Xianjing Hu, Congyan Zeng, Weibo Dai, Dawei Gao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-05308-2
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