Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells

Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity. However, broad-spectrum antioxidants that prevent ototoxicity compromise the anti-canc...

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Bibliographic Details
Main Authors: Shomaila Mehmood, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X25000271
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