Insulin resistance, Ca2+ signaling alterations and vascular dysfunction in prediabetes and metabolic syndrome

Insulin resistance, Ca2+ signaling alterations and vascular dysfunction in prediabetes and metabolic syndrome

Prediabetes and Metabolic Syndrome (MetS) share a common pathway to induce vascular dysfunction through hyperinsulinemia without the presence of overt hyperglycemia. Insulin resistance (IR) is a key factor in vascular complications in diabetes; however, vascular dysfunction has been reported in MetS...

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Bibliographic Details
Main Authors: Tatiana Romero-García, J. Gustavo Vázquez-Jiménez, Rommel Sánchez-Hernández, J. Alberto Olivares-Reyes, Angélica Rueda
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physiology
Subjects:
prediabetes
metabolic syndrome
vascular dysfunction
insulin signaling
calcium signaling
SERCA pump
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1535153/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1535153/full

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