Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.

Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation are poorly characterised. Here we present the...

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Main Authors: Michelle D Johnson, Michael Mueller, Martyna Adamowicz-Brice, Melissa J Collins, Pascal Gellert, Klio Maratou, Prashant K Srivastava, Maxime Rotival, Shahena Butt, Laurence Game, Santosh S Atanur, Nicholas Silver, Penny J Norsworthy, Sarah R Langley, Enrico Petretto, Michal Pravenec, Timothy J Aitman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1004813
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https://doi.org/10.1371/journal.pgen.1004813

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