Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP

Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP

Abstract Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparation solutions on LNP performance remains underexplored. This study systematically...

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Bibliographic Details
Main Authors: Siyuan Tang, Lei Huang, Jiahao Ge, Jie Li, Mingxia Qiu, Yiqing Zhang, Mei Long, Gang Wu, Rui Zhang, Xueyun Ma, Qiang Xia, Ping Wan, Taihua Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Lipid nanoparticle
Preparation process
Structure-activity relationship
Online Access:https://doi.org/10.1186/s12951-025-03318-w
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https://doi.org/10.1186/s12951-025-03318-w

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