Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells

Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells

Plasmacytoid dendritic cells (pDCs) are multifunctional immune cells with roles in both the innate and adaptive immune system. Their hallmark function is production of large amounts of type I interferons in response to viral infections, but they are also capable of producing a range of other cytokin...

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Bibliographic Details
Main Authors: Sabina Sánchez Hernández, Tobias Wang Bjerg, Ian Helstrup Nielsen, Anders Laustsen, Hai Q Tang, Lars Henning Pedersen, Eynav Klechevsky, Martin R. Jakobsen, Rasmus O. Bak
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
plasmacytoid dendritic cells
CD34 hematopoietic stem cells
in vitro differentiation
subsets
type I IFN
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550397/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550397/full

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